eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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4/2013
vol. 17
 
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abstract:
Original paper

Expression of HMGB1 and NF-κB p65 and its significance in non-small cell lung cancer

Xiaohong Zhang
,
Hongmin Wang
,
Jing Wang

Contemp Oncol (Pozn) 2013; 17 (4): 350–355
Online publish date: 2013/10/07
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Aim of the study: To study high mobility group protein B1 (HMGB1) and nuclear transcription factor p65 (NF-κB p65) ex­­pression in non-small cell lung cancer and its significance.

Material and methods: 106 hospitalized patients with non-small cell lung cancer after thoracic surgery were enrolled; HMGB1 and p65 protein expression was detected by the immunohistochemical method. Semiquantitative expression of HMGB1 and NF-κB p65 was analyzed using Image Pro Plus (IPP) software and statistical analysis.

Results: The rate of HMGB1 positive expression in the non-small cell lung cancer protein B1 family was significantly higher than normal tissues (P < 0.05); p65 protein expression in the non-small cell lung carcinoma group was significantly higher than that of normal tissues (P < 0.05). HMGB1 and NF-κB p65 protein expression was significantly higher compared with the non-metastatic group (P < 0.01). HMGB1 and NF-κB p65 protein expression showed a positive correlation (P < 0.05).

Conclusions: HMGB1 and NF-κB p65 ex­pression may be related to non-small cell lung cancer metastasis.
keywords:

non-small cell lung cancer, high mobility group protein B1, nuclear transcription factor p65, transfer, im­mu­nohistochemistry

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